Science Closer Than Ever to an HIV Cure

Scientists have confirmed that a 5th person has recently been cured from HIV. This patient joins an incredibly small group of people who have participated in treatments that have effectively eliminated HIV from their systems. Experts agree there is still a plethora of work and trials that need to take place before effective forms of large scale distribution can be applied to the more than 30 million people currently living with the disease. 

The news of another person cured from HIV brings hope to infected patients around the world, and suggests we are one step closer to finding a global cure. HIV has been studied rigorously over the past 50 years, leading to various methods to treat and manage symptoms of the disease, significantly extending patient’s lives and preventing pier-to-pier transmission. Much of the current treatment is focused primarily on reducing active viral loads found in a patient’s blood, and preventing HIV from advancing into its life threatening form as AIDS. 

As people afflicted with the disease are able to live longer and prevent further transmission, scientists are able to continue studying the harmful disease, searching for a global solution. More patient trials are scheduled to take place throughout the remainder of this decade as technology and new understanding of how to control the disease continue to advance bringing us one step closer towards a cure.  

History of HIV

HIV, otherwise known as the human immunodeficiency virus, attacks a person’s immune system increasing their likelihood of succumbing to other opportunistic infections and serious illness, effectively killing them. The disease is a lifelong affliction and can be easily transmitted through contact with the bodily fluids of another infected person. 

After contracting HIV a person may experience flu-like symptoms that gradually progress through the three stages of the disease before becoming life threatening. 

• Stage 1 Acute HIV Infection:

• Patient’s have a large quantity of HIV in their blood and are extremely contagious. 

• Patient’s exhibit many persistent flu-like symptoms like fever, sore throat, swollen glands, rash, muscle aches, fatigue. Etc.

• Stage 2 Chronic HIV Infection:

• The asymptomatic HIV infection stage where the disease is still active and producing within the body, but patients will likely not exhibit any symptoms. 

• Without treatment, the stage may continue for a decade or longer.

• Stage 3 Acquired Immunodeficiency Syndrome

• The most severe and life threatening stage of HIV infection.

• Patient’s have high viral load and can easily transmit the disease.

• Patient’s exhibit badly damaged immune systems exposing them to various opportunistic diseases and illnesses. 

• Without HIV treatment, people with AIDS typically only live up to three years after progressing to this stage. 

An HIV diagnosis is not life threatening with adequate treatment, however it is almost always fatal if the disease is left untreated and it advances into its later Stage 3 form as AIDs. There is no cure for HIV or AIDS, however doctors have developed significant advancements in medicine usage to effectively treat the symptoms of HIV, prevent its transmission, and extend the lives of infected people. 

There are currently 38.4 million people living with HIV, all who rely on the aid of modern medicines to remain alive. The disease has been dated back to the early 1800s, thought to originate from an interspecies transmission between chimpanzees and humans.The ape virus origins is thought to have entered human populations after hunters came into contact with the infected meat of a population of chimpanzees in Africa. Over the decades following the initial transfer, the disease spread across Africa and into the rest of the world spreading to the United States of America in the mid to late 1970s. 

How Stem Cells Cured HIV

The first patient ever cured from HIV was a German patient named Timothy Ray Brown in 2009. Timothy Brown was first infected with HIV in 1995 as a student in Berlin, where he successfully controlled his viral loads using medication. However his health took a significant turn for the worse in 2006 after he was diagnosed with leukemia. He was forced to undergo several operations, including a bone marrow transplant using stem cells.

Due to his positive HIV diagnosis, the doctors operated the allogeneic stem cell transplant using stem cells from a donor with the CCR5 gene mutilation which made them resistant to HIV infections. 

Mr. Brown was forced to halt his HIV medications when starting the stem cell treatment, although he continued to get tested for signs of HIV. As doctor’s continued to monitor him, they were unable to find any signs of HIV in his blood or body for the next three years after his transplant. Additional studies were also able to identify decreases in HIV specific blood antibodies indicating the elimination of functional HIV from his system. 

After presenting his patient case at the Conference on Retroviruses and Opportunistic Infections additional patients continued to be cured using the same methods.The other cured patients all underwent similar stem cell therapies to combat various forms of blood cancers. This method of treatment is not realistic over large scales because the human stem cell donors that bear the crucial CCR5 HIV resistant genetic mutation only account for approximately 1% of the global population, and stem cell transplantation is an extreme treatment with a myriad of associated risks.

Working Towards an HIV Cure

HIV is an incredibly complex virus that persistently spreads throughout a person’s body once infected. The disease can exhibit periods of latency while continuing to spread through cells in the body, even while under the medication of antiretrovirals (ARV). The main problem for scientists working towards a cure is finding a way to uncover and specifically target these hidden HIV cells that can unfortunately be reanimated if a patient stops using their medications, leading to reinfection.

The first step scientists are exploring on the road to a cure is to influence the hidden HIV cells to produce recognizable HIV proteins that medicine and the body can identify. Once the cells harboring the HIV are identified, specific drugs may be used to tag these cells for the immune system to exterminate. Patients will be given the treatment while continuously using the ARV medication to ensure healthy cells are protected from infection. 

The biggest problem scientists are facing developing this induce and reduce method, is reactivating the hidden HIV without causing health complications to the subject. However, with many of the world’s top scientists working diligently towards this solution, there have already been advances in types of effective medication for identification. 

The scientists remain optimistic that the world is closer than ever to having a cure for this disease. Moving forward, the studies will progress from laboratories into clinical trials, eventually determining the applications for the rest of the infected population. 

Human Rights Violations Amidst Qatar World Cup Controversies

This year’s Fifa World Cup will be held on November 20th in Doha, Qatar, and will be the first time in the Middle East. The overall cost of hosting this year’s world cup has been estimated at upwards of $200 billion USD as Qatar has invested in creating seven new stadium venues to host the 32 teams and 64 matches spanning the games. Controversies have plagued the developmental agenda for the Doha world cup since the country began its ambitious construction on the venues 10 years ago. As it draws nearer to completion, many controversies have been at the forefront of media coverage, with allegations of human rights violations and deaths throughout the development process. 

Committing to hosting the Fifa World Cup is a complex request as the event will attract more than 1 million attendees and close to 3 billion virtual spectators. Due to Qatar’s position in the middle east and economic standing, they had to establish all new venues to accommodate the influx of tourists that will arrive later this month. The overhead cost of $200 billion USD has contributed to developing those arenas, ceremonies, workshops, press, housing, and sales. The country has enlisted the help of hundreds of thousands of migrant workers over the last 10 years; however, human rights activists have highlighted the many unsafe conditions, low pay, and faulty system trapping workers in their jobs developing the venues. 

Many migrant workers coming to Qatar are from India, Pakistan, Nepal, and Bangladesh. They were promised substantially increased wages compared to their home countries, although many were unaware of the Qatari employment systems and conditions they would face. The daily life of migrant workers often includes 12 hours of manual labor in temperatures upwards of 100 degrees Fahrenheit. These people were delegated to live in squalid and overcrowded worker camps on the outskirts of developments. The exploitation continued as Qatar is one of the world’s richest per capita countries. It also has many complex employment laws governing its migrant workers. 

A major injustice argued by human rights activists included the highly controversial kafala system whereby migrant workers had to sign away rights to Qatari companies to get a sponsored visa. The sponsors withheld passports, rewrote contracts, and often withheld wages. Employers also required recruitment fees to be paid by workers forcing them into debt with the companies, going months without sending money back to their families in need. Migrants were entirely helpless as the systematic laws also prevented them from leaving the country, changing jobs, or protesting as demonstrating is illegal. 

Immense pressure from the world cup administration and fans resulted in reforming and removing the kafala system towards these migrant workers in 2019. The reformation did improve their working conditions; however, two years later, it is still evident that the weak implementation of the changes still resulted in missing wages, extraneous hours, outrageous recruitment fees, and legal dilemmas for migrant workers. Amnesty groups characterize the workers' condition as a form of modern slavery, with very little rights protection outlined in contracts and virtually no freedom to unionize or gather fair wages in these developments. 
The dangerous conditions have also resulted in tens of thousands of migrant deaths over the last decade in relation to the world cup developments. Many deaths have resulted in outcries from cup supporters and fans who want to see intense reformation in the Qatari facilitation of these people. While some reformations have begun, the weak implementation by officials and lack of resources delegated to the migrant worker has not improved the overall conditions and slavery-type work. The Fifa president and governing body have urged players and fans to focus on football and not to get dragged into the ideological or political battles surrounding the location of the games. Response to their statement has garnered mixed reviews as many amnesty groups condemned the views as hypocrisy and a stark ignorance of these serious human rights issues.

Autoimmune Diseases Linked to the Black Plague

The Black Death was an unimaginable pandemic that swept through Europe in the mid-1300s, resulting in catastrophic and severe mortality of the global population at the time. The seven-year plague was responsible for up to 200 million deaths, a significantly more significant impact than the current coronavirus pandemic responsible for around less than 6.6 million deaths. Researchers studying gene mutations and modern human DNA recently discovered links between historic Black Death survivors and autoimmune diseases currently affecting millions of people.  

The significance of the Black Death’s impact at the time also coincides with a much smaller global population of around 392 million people, explaining why the plague had such an enormous impact and required centuries for the world to recover from the devastation. The plague was responsible for removing 30 to 60 percent of the European population at the time, meaning many modern humans of European descent originated from the remaining survivors. 

The enormity of the plague’s impact shaped humanity’s evolution, forcing the selection of survivable traits, which the researchers could observe in skeletal remains and descendants of the survivors. DNA analyses from the skeletons of plague survivors discovered genetic mutations that may have been the reason for greater individual survivability. The DNA study published in Nature found a series of mutations around the ERAP2 gene, equating to a 40 percent greater chance of surviving the plague for sampled individuals. 

The ERAP2 gene is responsible for generating proteins that divide and disperse invading microbes to immune system defenses, allowing it to recognize and neutralize invaders effectively. Survivors of the plague had mutations creating a high-functioning version of the gene, allowing their immune systems to overcome any infections by the deadly disease better. These plague-resistant mutations are still prevalent in today’s modern society as they were passed down through generations. However, modern-day humans may be inadvertently affected by those same high-functioning qualities of the mutations.

The massive impact the Black Death had on earlier human populations has continued to affect modern-day society, implicating descendants of survivors with damaging health consequences. Scientists discovered the increased protein production from the high-functioning gene can be linked to various autoimmune disorders like the damaging inflammatory bowel disease called Chrons. Increased protein production by the specific genes consequently has a negative implication forcing the body to damage itself in response to minor microbial invasions or even the lack thereof. The correlation of the plague’s evolutionary impact to modern autoimmune diseases is baffling but will potentially lead to discoveries regarding these diseases’ origins and treatment. 

Human DNA studies are incredibly complex as they attempt to understand many factors like mutations, environmental pressure, survivability, and inheritance. Similar consequences caused by the Black Death are improbable in the wake of the ongoing coronavirus pandemic. Future descendants of covid survivors will not likely need to address mutation complications because of the low significant impact on global populations and the disease’s inability to impact humans over a diverse age spectrum. Coronavirus-19 statistically has the most significant impact on older people, with deaths over 65 accounting for more than 75 percent globally.

EPA Designates Forever Chemicals as Hazardous Substances

Synthetic human-made chemicals called PFAS have been rapidly infiltrating many of the world’s vital water supplies, damaging Earth’s environment in the process. These per-and polyfluoroalkyl substances (PFAS) are incredibly difficult to break down, often lasting for thousands of years, even contaminating rainfall in certain regions. With increasing knowledge over the last few decades, the United States Environmental Protection Agency (EPA) has decided to submit an official proposal to classify many of these chemicals as hazardous substances, influencing many additional federal protocols associated with their use and disposal. The decision also comes as new research has been exploring better ways for PFAS management and disposal. 

Many PFAS are common household products like cooking pans, oils, cleaning supplies, and abrasives. PFAS chemicals often produce coatings and products that can repel water, oil, heat, and grease. The chemicals are dangerous because they break down slowly and have been observed leaching into water and soil, leaving trace amounts detectable in the blood of humans and animals. 

Recent studies about the effects of exposure to PFAS suggest earlier assumptions were incredibly limited concerning the risks and knowledge of dangerous exposure levels. Prolonged exposure can result in reproductive complications, heart issues, respiratory disease, cancer, and immunosuppressant responses in communities. PFAS causes various complications as they primarily settle in the body’s blood, kidneys, and liver. These chemicals have been in the commercial market since the 1940s, and previous studies suggest they are present in more than 98 percent of the US population. 

The EPA’s submitted proposal will list at least two of these harmful PFAS as hazardous substances, encouraging effective waste management at facilities that handle these chemicals, with much more likely to be added later. The Federal Drug Administration and many chemical manufacturers have already voluntarily phased out the use of these chemicals, especially in commodities that deal directly with food products. However, the unfortunate reality still suggests more than 70 percent of imported products still contain remnants of older PFAS. Since these chemicals are so slow to break down, they easily contaminate products transported into air, dust, food, ground soil, and water.  

The EPA’s decision to begin managing PFAS use and disposal has had to navigate complicated relationships with the prominent chemical industry leaders, but at the neglect of community and environmental health. Critics of the EPA’s new proposal claim the action is a little too late, without any real repercussions or plans to mitigate the damages from the prolonged incorporation of these harmful chemicals in American communities. The other misfall of the EPA’s new proposal is that it fails to address any future solutions, only acknowledging current problems and only a few harmful PFAS. 

There is little acknowledgment in the proposal to develop plans for future mitigation as these hazardous chemicals continue to leach into the environment and are already waning vital resources of fresh water. Although the proposal may lack future mitigation efforts, chemical scientists have been researching how to dispose of these chemicals effectively, and there may still be some good news. 

Scientists have discovered that effective use of heat in contaminated water can initiate a chemical reaction to break down the strong PFAS bonds, removing them from the water without any remaining byproducts. This new information means water processing plants can effectively remove the harmful PFAS from water without releasing any byproducts into the environment, gradually diminishing their communal effects globally.

UN Leaders Urging Companies to Take Measures to Protect Seafarers’ Rights

The United Nations has issued a list of human rights to business enterprises that are engaged in the maritime industry to protect seafarers that may be stranded on ships due to new COVID-19 variants and government-imposed travel restrictions. The Human Rights Due Diligence Tool is a joint initiative by the UN Global Compact, UN Human Rights Office, International Labour Organization (ILO), and the International Maritime Organization (IMO).

The tool provides guidance and a checklist for cargo owners, charterers, and logistics providers to conduct human rights due diligence across their supply chains to identify, prevent, mitigate and address adverse human rights impacts for seafarers. 

Amid concerns about the number of crew stranded working beyond their contacts at sea due to COVID-19 restrictions, UN agencies hope the new guidance will help ensure that the working conditions are respected and comply with international standards. The guidance aims to ensure that seafarers have rights safeguarded, such as physical and mental health, and access to family life, and freedom of movement. 

Although the maritime industry contributes more than 80% of global trade goods, there have been reports that seafarers are working way beyond the 11-month maximum limit of service on board. An estimated 200,000 crew are stuck on commercial vessels globally amid recent attempts to prevent the spread of COVID-19. Unilever and other big retail brands are among consumer giants adopting a toolkit to audit their shipping supply chains to help bring seafarers stuck on commercial vessels back home and eliminate human rights risks. 

Any company that puts any cargo on ships will be encouraged to use the checklist, which includes asking ship owners and those who charter space on vessels to support crew changes and ensure clauses aren’t being added to contracts that prevent crew relief.